From Oakland / San Francisco & Points North:
Take I-80 West toward San Francisco. I-80 West becomes US-101 South. Take US-101 South toward San Jose for 16.8 miles. Take the 3rd Avenue exit onto 3rd Ave West, follow for 0.8 mile. Turn right on S San Mateo Drive, follow for 0.2 mile. Arrive at 50 S San Mateo Drive.

From Palo Alto & Points South:
Take US-101 North toward San Francisco, follow for 12.4 miles. Take the CA-92 exit toward Half Moon Bay, follow for 1.1 mile. Take the El Camino Real North exit, go 1.3 mile. Turn right on 2nd Avenue, follow for 0.1 mile. Turn left on S San Mateo Drive, follow for 0.1 mile. Arrive at 50 S San Mateo Drive.

From Points East:
Take CA-92 go 14.2 miles. Take the El Camino Real North exit, go 1.3 mile. Turn right on 2nd Avenue, follow for 0.1 mile. Turn left on S San Mateo Drive, follow for 0.1 mile. Arrive at 50 S San Mateo Drive.